Signal Transduction Reagents and Kits
Medchemexpress LLC Syk-IN-4 | 2932264-95-2 | 98.0% | C21H25N9O | 10MG
Potent, selective, orally bioavailable spleen tyrosine kinase (SYK) inhibitor with sub-nanomolar potency (IC50 = 0.31 nM). Characterized for in vivo oral exposure and intended for research into autoimmune disorders and hematologic cancers. Supplied as a high-purity white to off-white solid with documented solubility and storage recommendations.
- Sub-nanomolar inhibitory potency against SYK (IC50 = 0.31 nM).
- Orally bioavailable with demonstrated oral exposure in rodent models.
- High purity suitable for biochemical and cellular assays.
- Well-characterized solubility protocols for in vivo formulation.
- Stable under recommended storage conditions.
Revvity Health Sciences Inc HTRF Human Phospho-STAT3 (Tyr705) Detection Kit, 50,000 Assay Points
HTRF Human Phospho-STAT3 (Tyr705) Detection Kit, 50,000 Assay Points
Abcam Citrate Assay Kit
Citrate Assay Kit
The product is subject to the following: Abcam Restricted Use Statement
Enzo Life Sciences Lysophosphatidic acid (25mg). CAS: 325465-93-8
Lysophosphatidic acid (LPA) is a multifunctional intercellular phospholipid messenger. LPA stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes. It acts as a proliferative and anti-apoptotic factor. Ligand for LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors. It also inhibits differentiation of neural stem cells into neurons. Alternative name: 1-Oleoyl-lysophosphatidic acid . sodium salt. Purity: ≥98% (TLC). Solubility: Soluble in water (5 mg/mL with sonication) or DMSO (0.5 mg/mL warm). Long Term Storage: -20°C.
Creative Biomart Galsulfase, Human N-acetylgalactosamine 4-sulfatase
The product is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. The product is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate manose7 oligosaccharide for specific cellular recognition. Post-translational modification of Cys53 produces the catalytic amino acid residue Ca-formylglycine, which is required for enzyme activity and is conserved in all members of the sulfatase enzyme family.
Echelon Biosciences Research Labs XY-17 (LPA3 Agonist) 0.5 mg
XY-17 is a fluorinated phosphonate analog of lysophosphatidic acid (LPA). XY-17 is not hydrolyzed by lipid phosphate phosphatase (LPP) and acts as an agonist of the LPA3 receptor. This item is non returnable
Creative Biomart Alglucosidase alfa, Recombinant Human enzyme acid alpha-glucosidase (GAA)
The product consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes. It is encoded by the most predominant of nine observed haplotypes of this gene. The product is produced by recombinant DNA technology in a Chinese hamster ovary cell line. The product degrades glycogen by catalyzing the hydrolysis of a-1,4- and a-1,6- glycosidic linkages of lysosomal glycogen. Structurally, the product is a glycoprotein with a calculated mass of 98,008 daltons for the 883 residue mature polypeptide chain, and a total mass of approximately 109,000 daltons, including carbohydrates.
Montana Molecular Green Ratiometric Cilia-Targeted cADDis cAMP Sensor Kit D0211G, 10mL, CMV
Measure real-time cAMP signaling kinetics in the primary cilia with this live cell fluorescent assay. Add cADDis to your cells and measure robust signals the next day on a fluorescence imaging system. Decreasing green fluorescence indicates ciliary cAMP increase. Constitutively expressed cytosolic red fluorescence can be used for ratiometric measurements. This assay is genetically encoded and packaged in BacMam for efficient delivery to cilia in most cell types, including many primary and iPSC-derived cells.
Apexbio Technology LLC highly selective, potent and cell-permeable p38 MAPK inhibitor 152121-30-7. MFCD00941964
highly selective, potent and cell-permeable p38 MAPK inhibitor 152121-30-7. MFCD00941964
Echelon Biosciences Research Labs Calpain Inhibitor III Z-VF-CHO - 10 mg, CAS#: 88191-84-8
Calpain Inhibitor III Z-VF-CHO - 10mg , Z-Val-Phe-CHO This item is non returnable
Echelon Biosciences Research Labs Gamma Secretase Inhibitor - 5 mg, CAS#: 133407-83-7
Gamma Secretase Inhibitor - 5mg , Z-Leu-Leu-Nle-CHO Category/Application: Enzyme Substrates This item is non returnable
Echelon Biosciences Research Labs PI(5)P DIC8 AMMONIUM SALT 500 ug
Phosphatidylinositol 5-phosphate diC8 (PI(5)P diC8) is a synthetic, purified dioctanoyl PI(5)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 5-phosphate (PI(5)P) is a rare lipid found in the nucleus that can bind the PHD finger of the nuclear adapter protein ING2. PI(5)P is phosphorylated to PI(4,5)P2 by Type II PIP kinases. This item is non returnable